Reactive Oxygen Species (ROS) Signaling: Regulatory Mechanisms and Pathophysiological Roles
نویسندگان
چکیده
منابع مشابه
Toxicological and pathophysiological roles of reactive oxygen and nitrogen species.
'Oxidative and Nitrative Stress in Toxicology and Disease' was the subject of a symposium held at the EUROTOX meeting in Dresden 15th September 2009. Reactive oxygen (ROS) and reactive nitrogen species (RNS) produced during tissue pathogenesis and in response to viral or chemical toxicants, induce a complex series of downstream adaptive and reparative events driven by the associated oxidative a...
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We sought to understand the relationship between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT) in cardiac myocytes based on the observation of increased ROS production at sites of spontaneously deenergized mitochondria. We devised a new model enabling incremental ROS accumulation in individual mitochondria in isolated cardiac myocytes via photoactivation of t...
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Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of potentially damaging levels of reactive oxygen species (ROS), Ca(2+), etc., which must be normalized. Evidence suggests that brief mitochondrial permeability transition pore (mPTP) openings play an important physiological role maintaining healthy mitochondria homeostasis. Adaptive and maladaptive responses to r...
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ion, hydrogen addition or electron transfer, while superoxide anion reacts via only hydrogen abstraction and electron transfer (Section 1.2) (5). Although, hydrogen peroxide and singlet oxygen are classified as ROS, they are not radicals and do not necessarily interact with tissue through radical reactions directly (6). Hence, they are not toxic per se but in presence of free radicals or cataly...
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Oxidative energy production is inevitably associated with the generation of reactive oxygen species (ROS), excessive concentrations of which can lead to cellular pathol‐ ogy. A free radical may be defined as any molecule that has one or more unpaired electrons. The superoxide anion, the hydroxyl radical, and the hypochlorite radical are some of the highest reactive radicals of oxygen. Owing to ...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2019
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.19-00141